How Does CBD Interact with Medication

Published May 1, 2021 • Spinfuel Editorial Lab

The Lab Notes: Key Takeaways

CBD-infused products became a popular solution to health issues such as seizures, anxiety, depression, or chronic pain. However, you might be wondering how they interact with over-the-counter and prescription medications. Are they safe? Can you use them with other supplements…

CBD-infused products became a popular solution to health issues such as seizures, anxiety, depression, or chronic pain. However, you might be wondering how they interact with over-the-counter and prescription medications. Are they safe? Can you use them with other supplements and herbal remedies? As CBD is a biologically active compound, answering these questions is essential if you want to avoid severe consequences. Luckily, while CBD is a relatively new substance, there are some studies that can help us better understand how it can interact with medications.

How Does CBD Interact with Medication?

If you would like to learn more about CBD and its possible side effects, you came to the right place. Here is what you need to know about it and how it might interact with other medications.

How CBD Works

Before we discuss how CBD interacts with other medications, it’s helpful to understand its mechanism. CBD, a compound derived from hemp and cannabis plants, is available in various forms, including oil, green apple CBD gummies, and vape cartridges. It belongs to the chemical family known as cannabinoids. The quality of CBD can be influenced by many factors. If you’re considering products from your own plant, ensure you source from the best seed banks available to guarantee a high-quality product.

This particular chemical possesses numerous properties, including the ability to interact with our endocannabinoid system (ECS). The ECS is a complex network responsible for regulating several vital processes throughout our body.

In fact, the ECS is the primary reason why CBD exhibits such diverse biological effects. Beyond its interaction with this system, CBD also engages with various receptors in our body, allowing it to modulate functions such as pain, inflammation, mood, and appetite. However, CBD does not bind directly to cannabinoid receptors. Instead, it interacts with some of the serotonin receptors in our brain, which explains its potential effect on mood and its possible interactions with certain medications.

Specifically, the serotonin 5-HT1A receptor appears to be a key interaction point for CBD. It seems that CBD doesn’t directly alter these receptors but acts more as a modulator, implying only slight effects on them. Nevertheless, further research is necessary to draw more concrete conclusions.

Medicines That Interact With CBD

Given that CBD interacts with some of the serotonin receptors in our brain, certain medications may also interact with it. But which medications, and how severe are these interactions? The following list provides examples of medications that may interact with CBD:

Antidepressants

Some antidepressants appear to interact with CBD due to similar serotonin receptor activity. These interactions could lead to changes in the efficacy of either drug or result in side effects. One study reported that CBD increased the antidepressant effect of certain antidepressants. However, other research suggests that CBD can decrease the effectiveness of certain antidepressants. To avoid potential interactions with your medication, it is always best to consult your doctor first.

Specific antidepressants, such as SSRIs (selective serotonin reuptake inhibitors), are known to interact with CBD. This interaction can be significant, potentially rendering the combination not only ineffective but also dangerous. If you are taking any of these medications, it is highly advisable to speak with your doctor before considering CBD use.

Antipsychotic Medication

Antipsychotics are frequently prescribed for conditions like schizophrenia and other mental health disorders. However, they can cause various side effects, including drowsiness and dry mouth. Since CBD also has sedative effects, its concurrent use with antipsychotics can increase the risk of developing these side effects. If you are on antipsychotics and wish to use CBD-infused products, you should consult your doctor first and closely monitor for any potential side effects.

Stimulants

Similar to antipsychotics and antidepressants, stimulants may interact with CBD due to their shared serotonin receptor activities. Stimulants are often used to treat ADHD and even asthma attacks. However, they can also cause side effects such as anxiety and insomnia. If you use stimulant medication and are considering CBD-infused products, discuss it with your doctor. They can help you assess whether these products are safe for you to use alongside stimulants.

Opioid Medication

Opioids are among the most prescribed types of medications in the United States, used for treating moderate to severe pain. They come with side effects such as vomiting and nausea. Some studies indicate that using CBD together with opioids might significantly reduce these side effects. However, more research is needed before definitive conclusions can be drawn about this interaction between opioids and CBD-infused products.

Anti-anxiety Medication

Anti-anxiety medications include benzodiazepines (e.g., Xanax), barbiturates (e.g., Phenobarbital), and other similar drugs (e.g., Valium).

Other Medication

Several other medications may interact with CBD. For instance, anticonvulsants and antihypertensives might have interactions with CBD. Generally, these interactions are mild and can often be managed by adjusting your dosage or switching to a different medication. If you are using any of these medications, consult your doctor before using CBD-infused products.

It is crucial to reiterate that more research is needed before we can make any final conclusions about how CBD interacts with other medications. Therefore, if you are currently taking any medication and are considering using CBD-infused products, always speak with your doctor first. They will help you evaluate whether or not these products are safe for you to use while taking other medications.

CBD Side Effects

In addition to interacting with certain medications, CBD might also cause some side effects. As previously mentioned, CBD directly interacts with serotonin receptors in our brain. While its effects on these receptors may be slight, this can still lead to some mild side effects.

The most common side effect associated with CBD is drowsiness. Some individuals who consume too much CBD may experience drowsiness. If this occurs, you should reduce your intake until you determine a safe dosage for your use.

Some research also suggests that CBD can decrease blood pressure and heart rate. One study, for example, showed that a single dose of 600 mg of CBD could result in a 15 percent drop in blood pressure. This decrease may be undesirable for individuals who already have low blood pressure or existing heart problems. Therefore, if you are taking any medications and considering using CBD-infused products, it’s always best to consult your doctor first.

Medication and Supplements

CBD interacts with some medications and supplements due to similar serotonin receptor activities. However, these interactions are generally mild and can often be managed by adjusting your dosage or switching to a different medication.

If you are taking any medication and are considering using CBD-infused products, talk to your doctor first. They will help you evaluate whether or not these products are safe for you to use while taking other medications. You can also find out more about the possible side effects of CBD-infused products by reading our article What Are the Benefits of CBD?

Final Thoughts

As you can see, there are a few medications that can interact with CBD. Interactions are generally not very severe and can often be avoided by using CBD-infused products according to your doctor’s instructions. If you are seeking an alternative treatment for your health condition, CBD-infused products might be a great option. However, if you decide to use them, you should first discuss with your doctor how they might affect your current medication. If you have any questions about this article or would like to learn more about CBD-infused products, feel free to leave a comment below. We’ll gladly help you out!