Lost Vape Therion DNA 166 Box Mod Review
The Lost Vape Therion DNA 166 is a high-performance box mod, leveraging the robust DNA 166 chipset from Evolv. Known for its sophisticated temperature control suite and customizability, the Therion DNA 166 delivers an exceptional vaping experience housed within a stylish and ergonomic design. This review delves into its features, performance, and overall value for advanced vapers.
Lost Vape has a reputation for crafting premium vape devices, and the Therion series is a prime example of their dedication to quality and performance. The DNA 166 version builds upon the success of its predecessors, offering more power and refined aesthetics.
What’s in the Box?
- 1x Therion DNA 166 Box Mod
- 1x USB Charging Cable
- 1x Therion DNA 166 User Manual
- 1x USB Manual
- 1x Warranty Registration Card
Key Features of the Therion DNA 166
- Dual 18650 Battery (not included)
- Temperature Control Mode
- Customization via Evolv’s EScribe Software
- Leather Battery Cover
- Variety of Wood/Carbon Fiber/Kevlar Accent Panels
- Nickel Plated Brass 510 Pin
- Stainless Steel Threading
- Firmware Upgradable
- 0.91 inch OLED Screen
- Micro USB Charging & Escribe Connectivity
Therion DNA 166 Specifications:
- Dimensions: 90mm x 54mm x 27mm
- Output Power: 1 – 166 Watts
- Temperature Range: 200°F – 600°F
- Min Kanthal Resistance: 0.10 Ohm
- Min Temperature Resistance: 0.08 Ohm
DNA 166 Features & Performance

The Evolv DNA 166 Chipset
At the heart of the Therion DNA 166 is the Evolv DNA 166 chipset, one of the most advanced and reliable chipsets in the vaping industry. This chip is effectively a DNA 250 chip with output limited to 166W, designed for dual-18650 battery configurations. It offers unparalleled accuracy in wattage output and temperature control, making it a favorite among experienced vapers who demand precision.
Performance in Wattage Mode
In wattage mode, the Therion DNA 166 delivers power smoothly and consistently across its entire range, from 1W up to 166W. Vapor production is immediate and robust, with no noticeable delay. Whether you’re using a single-coil RTA or a high-wattage sub-ohm tank, the Therion 166 handles it with ease. The power delivery feels very consistent, providing a satisfying vape every time.
Advanced Temperature Control
The DNA 166 excels in temperature control (TC). It supports a wide array of TC wires including Nickel (Ni200), Titanium (Ti), and Stainless Steel (SS316, SS304, SS317). Through Evolv’s EScribe software, users can create custom profiles for virtually any wire type, fine-tuning their TC experience to perfection. This level of customization ensures a consistent and flavorful vape, preventing dry hits and extending coil life.
EScribe Software
The true power of the DNA 166 lies in its compatibility with Evolv’s EScribe software. This desktop application allows users to deeply customize almost every aspect of their device. From setting preheat curves and resistance locks to changing screen themes and monitoring battery performance, EScribe offers an unmatched level of control. While it has a learning curve, the benefits for advanced users are immense.
The Lost Vape Therion DNA 166 in Detail
Design and Ergonomics
Lost Vape has consistently impressed with its design aesthetic, and the Therion DNA 166 is no exception. It features a premium zinc alloy chassis with genuine leather battery wraps and accent panels made from various materials like carbon fiber, wood, or Kevlar. This blend of materials gives the Therion a luxurious feel and makes each mod unique. The mod fits comfortably in the hand, and the weight (without batteries) feels substantial without being overly heavy.

Battery Compartment
The dual 18650 batteries are housed behind a magnetic leather-wrapped battery door. The magnets are strong, holding the door firmly in place with no rattling or wiggle. The battery door is easy to remove and replace, making battery swaps quick and convenient.
Battery Sled
The battery sled is clearly marked with positive and negative indicators, ensuring correct battery orientation. The contacts are gold-plated for optimal conductivity. Lost Vape’s sled design is known for being robust and reliable.
Display Screen
The 0.91-inch OLED screen is bright and clear, displaying all essential vaping information such as wattage, temperature, resistance, battery life, and puff count. While not a color screen, it is highly legible in various lighting conditions. Customization of the display is also possible through EScribe.
Buttons
The fire button is large, tactile, and responsive, located ergonomically for thumb or finger firing. The adjustment buttons (+/-) are smaller but equally clicky and well-placed. All buttons have a premium feel, indicating good manufacturing quality.
510 Connector
The Therion DNA 166 features a spring-loaded nickel-plated brass 510 connector with stainless steel threading. This ensures excellent conductivity and compatibility with a wide range of atomizers up to 25mm without overhang. Atomizers sit flush, and the connection is solid.
The Conclusion
The Lost Vape Therion DNA 166 is undoubtedly a high-end box mod designed for discerning vapers who appreciate both aesthetics and performance. The Evolv DNA 166 chipset delivers precise and customizable vaping, making it suitable for both wattage and advanced temperature control enthusiasts.
Its premium build quality, genuine leather, and exquisite accent panels make it stand out from the crowd. While the EScribe software might intimidate beginners, it unlocks the full potential of this device for those willing to invest the time.

Spinfuel Choice Award
Rating: A+
Recommendation
We highly recommend the Lost Vape Therion DNA 166 to experienced vapers looking for a reliable, powerful, and aesthetically pleasing device with extensive customization options. If you’re new to vaping or prefer simpler devices, the learning curve with EScribe might be a deterrent. However, for those who demand the best, the Therion DNA 166 is an excellent investment.
Remember to always practice battery safety and use high-quality, authentic 18650 batteries.



